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PubMed PMID: 9547571
7-dioxa-21-azapentacyclo[11
InChi: InChI=1S/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3
CAS Number: 146986-50-7
A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas
AZ 628 Size:Solid 2 mg PubMed PMID: 9547571AZ 628 is a selective, orally available Raf inhibitor with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies ( (IC50 values are 29, 34 and 105 nM for c Raf1, B RafV600E and wild type B Raf, respectively). AZ 628 inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B RafV600E mutation. Product information CAS Number: 878739 06 1 Molecular Weight: 451. 52
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